[HTML][HTML] Generate-Boost: study protocol for a prospective, multicenter, randomized controlled, double-blinded phase II trial to evaluate efficacy and safety of …
J Wickel, HY Chung, S Platzer, T Lehmann… - …, 2020 - trialsjournal.biomedcentral.com
Autoimmune encephalitis is a new spectrum of autoimmune disorders of the central nervous
system (CNS), which are characterized by pathogenic autoantibodies against neuronal
surface antigens. Clinical presentations range from acute to subacute encephalopathy with
neurological and psychiatric symptoms, and life-threatening autonomic dysfunction in
severe cases. There exist no approved therapies nor is data available from controlled
clinical trials. Patients are usually treated with diverse combinations of immunotherapy …
system (CNS), which are characterized by pathogenic autoantibodies against neuronal
surface antigens. Clinical presentations range from acute to subacute encephalopathy with
neurological and psychiatric symptoms, and life-threatening autonomic dysfunction in
severe cases. There exist no approved therapies nor is data available from controlled
clinical trials. Patients are usually treated with diverse combinations of immunotherapy …
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